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KMID : 0381920150450030135
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Korean Journal of Microscopy
2015 Volume.45 No. 3 p.135 ~ p.143
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The Effect of Joint Mobilization on the Expressions of Nadph-Diaphorase and Nitric Oxide Synthase in the Spinal Cord Neurons
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Toshifumi Kuwaoka
Jung Han-Suk
Ham Joo-Hyun
Choi Jin-Ok
Cho Hye-Rin
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Abstract
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The aim of this study was to investigate effects on joint mobilization in neurochemical changes of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and nitric oxide synthase (NOS) of the spinal cord neurons after right knee joint immobilization (RKJI) and in ultrastructural changes of the femoral nerves innervating the muscles acting on RKJI. A total of 15 guinea pigs were used and divided into 5 groups. Immunohistochemistry was performed to detect NADPH-d and NOS. NADPH-d and NOS were not expressed in the ventral horn of control and experimental groups, but were expressed or not in the dorsal horn according to the duration of release after RKJI and the presence or absence of joint mobilization. Ultrastructures of the femoral nerves in experimental groups had partial demyelination and condensed clumps in axon. Effects on manipulative therapy after RKJI were confirmed from expression of NADPH-d and NOS in the dorsal horn of the lumbosacral spinal cord. Manipulative therapy was more effective against a long-term immobilization than a short-term immobilization.
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KEYWORD
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Knee joint, Joint mobilization, Nicotinamide adenine dinucleotide phosphatediaphorase, Nitric oxide synthase, Immobilization
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